Modern Uses and Sources of Human Chorionic Gonadotropin

Human chorionic gonadotropin (HCG) is naturally and perfectly designed to help sustain life by stimulating production and secretion of progesterone, the life-maintaining hormone, at the start of conception. Hence, it is essentially correlated with reproduction. However, science had revealed that HCG is structurally and mechanically analogous to luteinizing hormones (LH). Such uncanny relationship has generated more studies on alternative uses of HCG in medicine and sports.

hcgsourceFor several years, HCG formulations have been used in lieu of the mid-cycle LH surge. The capabilities of human chorionic gonadotropin to duplicate the actions of luteinizing hormones in life events have made HCG a go-to substance in situations or processes where LH is unavailable or in low supplies.

More extensive scientific studies and clinical evidence have exposed the application of HCG’s LH-like properties in wellness, health, fertility therapies, and medical treatments.

HCG is now extensively used in modern assisted reproductive techniques involving intrauterine insemination and in-vitro fertilization in combination with other gonadotropin hormones. It is used to support the ovulatory phase of treatment programs using clomiphene, a fertility drug formulated to stimulate egg development and ovulation.

HCG can be used to treat low sperm counts by raising testosterone to its normal levels through a regular injection regimen lasting up to 6 months. Treatment continues to its next stage even after normal testosterone levels are achieved as the shots work to stimulate the sperm count to stabilize or normalize.

The testosterone-raising abilities that HCG shares with luteinizing hormones make it a perfect replacement for LH in sports or bodybuilding. To bulk up, achieve recovery, and enhance performance faster, athletes often resort to the use of steroids. Anabolic androgenic steroids (AAS) cycles cause LH to halt the production of testosterone. This happens because of negative feedback mechanisms in the body that are activated when body-altering steroids make their entry.

hcgIn routine drug-testing, low testosterone levels indicate usage of steroids, which are actually banned substances. The use of HCG in place of the luteinizing hormone replenishes testosterone levels in the body and disguises the use of anabolic steroids. HCG secretes testosterone in generous amounts which hastens body repair and muscle buildup, making it a popular substance among athletes.Its expansive role in vital life-maintaining processes has placed the human chorionic gonadotropin hormone in the center of scrutiny by consumers and the medical community. Much of the questions on HCG arise due to the processes involved in its harvest and artificial production.

There are only two approved sources of human chorionic gonadotropin preparations at present. The earliest source was urinary in nature. The recombinant DNA source would come later as biotechnology made its advances in recent years.

The convenience of harvesting pregnant women’s urine and its widespread availability made the urinary source an acceptable choice for manufacturers and fertility specialists for the past years. There were some reports that seem to imply that the chemical analysis of HCG urine-sourced preparations seem to differ to some degree with the properties displayed by HCG naturally secreted by the placenta. This raises some questions on the full potency of urine-sourced HCG.

Serious concerns were also expectedly raised by consumers regarding the purity of its raw materials, its processing or extraction, as well as the lifelong safety of the urinary preparation.

The emergence of recombinant DNA technology has broadened the horizon for consumers and doctors. Recombinant HCG (r-HCG) is now available as an alternative in treatments and procedures requiring the use of HCG.
Recombinant DNA and urinary preparations are closely identical in their pharmacokinetic and pharmacodynamic details. In many clinical trials on the comparative effectiveness of urinary HCG (u-HCG) and recombinant HCG (r-HCG), the latter has exhibited the same level of efficacy as that of u-HCG in replicating processes associated with luteinizing